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Revolutionizing Musculoskeletal Health through microcapsule drug delivery

Harnessing the power of the body's own natural forces to deliver therapeutics

About Us

Innovative Drug Delivery Technology

Mechano Therapeutics is a biotech company specializing in microcapsule development using proprietary microfluidics for drug encapsulation. Our mission is to revolutionize musculoskeletal health using our innovative platform technology to enhance delivery of therapeutics for improving patient outcomes.

Microcapsule Platform

Our microcapsule platform technology offers a totally new approach of delivering therapeutics by encapsulating existing and novel drugs into the articulating joint whereby it activates drug release with force or motion

University of Penn Spin Out

Spun out of the University of Pennsylvania, we leveraged our understanding of mechanobiology and orthopedics to develop the first drug delivery system that uses natural mechanical forces of the joint to control delivery of therapeutics

Advantages of mamc Drug delivery

Targeted & controlled local release

Directive therapy and fewer potential systemic side effects

Stimuli responsive drug activation

Targeted & controlled local release

Release drugs 'on demand' based on mechanical forces of the joint

Dose sparing

Sustained bioavailability & enhanced biocompatibility

Maintains drug concentrations within the therapeutic range and fewer joint injections

Sustained bioavailability & enhanced biocompatibility

Preserves drug activity and improves drug efficacy in joint tissues

Publications & Patents

1. Mohanraj B, Duan G, Peredo A, et al. Mechanically-Activated Microcapsules for 'On-Demand' Drug Delivery in Dynamically Loaded Musculoskeletal Tissues. Advanced Functional Materials. 2019;29(15). doi: 10.1002/adfm.201807909. (Link)

2. Peredo AP, Jo YK, Duan G, Dodge GR, Lee D, Mauck RL. Mechano-activated biomolecule release in regenerating load-bearing tissue microenvironments. Biomaterials. 2021;265:120255. doi: 10.1016/j.biomaterials.2020.120255. (Link)

3. Jo YK , Heo SJ , Peredo AP , Mauck RL , Dodge GR , Lee D . Stretch-responsive adhesive microcapsules for strain-regulated antibiotic release from fabric wound dressings. Biomaterial Science. 2021 Aug 7;9(15):5136-5143. doi: 10.1039/d1bm00628b. (Link)

4. Zlotnick HM, Locke RC, Hemdev S, Stoeckl BD, Gupta S, Peredo AP, Steinberg DR, Carey JL, Lee D, Dodge GR, Mauck RL. Gravity-based patterning of osteogenic factors to preserve bone structure after osteochondral injury in a large animal model. Biofabrication. 2022 Jul 5;14(4):10.1088/1758-5090/ac79cd. doi: 10.1088/1758-5090/ac79cd. (Link)

Patents: Technology

PCT/US2016/035220 (USA) Mechano-sensitive microcapsules for drug delivery (filed: 12/1/2017)

PCT/US2016/035220 (Europe) Mechano-sensitive microcapsules for drug delivery (filed: 6/1/2016)

63/167,260 (USA) Mussel-inspired adhesive microcapsules for a stretch-responsive therapeutic delivery (filed: 3/29/21)

Drug Encapsulated MAMCs

Our team

George Dodge, PhD

NicK DePhillipo, PhD, MBA

CEO & Co-founder

NicK DePhillipo, PhD, MBA

COO

Bhavana Mohanraj, PhD

NicK DePhillipo, PhD, MBA

Bhavana Mohanraj, PhD

Co-founder

Bioengineer

Robert Mauck, PhD

Giuseppe Di Vitantonio, PhD

Bhavana Mohanraj, PhD

Co-founder

Bioengineer

Daeyeon Lee, PhD

Giuseppe Di Vitantonio, PhD

Co-founder

Chemical Engineer

Giuseppe Di Vitantonio, PhD

Consultant

Chemical Engineer

Ferit Tuzer, PhD

Senior Scientist

Molecular Biology

Aidan Bell, BS

Ferit Tuzer, PhD

Research Associate

Bioengineer

John Kelly, MD

Ferit Tuzer, PhD

Joost de Bruijn, PhD

Advisor

Orthopedic Surgeon

Joost de Bruijn, PhD

Advisor

CEO, Kuros Biosciences

Michael Lark, PhD

Joost de Bruijn, PhD

Hannah Zlotnick, PhD

Advisor

President, Lark Pharma Consulting

Revolutionizing Musculoskeletal Health through microcapsule drug delivery

About Us

Innovative Drug Delivery Technology

Microcapsule Platform

University of Penn Spin Out

Our Technology

Mechano-Activated Microcapsules (MAMCs)

Advantages of mamc Drug delivery

Targeted & controlled local release

Targeted & controlled local release

Targeted & controlled local release

Stimuli responsive drug activation

Targeted & controlled local release

Targeted & controlled local release

Dose sparing

Sustained bioavailability & enhanced biocompatibility

Sustained bioavailability & enhanced biocompatibility

Sustained bioavailability & enhanced biocompatibility

Sustained bioavailability & enhanced biocompatibility

Sustained bioavailability & enhanced biocompatibility

Publications & Patents

Patents: Technology

Drug Encapsulated MAMCs

Our Partners

Research & Development

Research & Development

Research & Development

Business Development

Research & Development

Research & Development

Early-Stage Financing

Research & Development

Early-Stage Financing

Our team

George Dodge, PhD

NicK DePhillipo, PhD, MBA

NicK DePhillipo, PhD, MBA

NicK DePhillipo, PhD, MBA

NicK DePhillipo, PhD, MBA

NicK DePhillipo, PhD, MBA

Bhavana Mohanraj, PhD

NicK DePhillipo, PhD, MBA

Bhavana Mohanraj, PhD

Robert Mauck, PhD

Giuseppe Di Vitantonio, PhD

Bhavana Mohanraj, PhD

Daeyeon Lee, PhD

Giuseppe Di Vitantonio, PhD

Giuseppe Di Vitantonio, PhD

Giuseppe Di Vitantonio, PhD

Giuseppe Di Vitantonio, PhD

Giuseppe Di Vitantonio, PhD

Ferit Tuzer, PhD

Ferit Tuzer, PhD

Ferit Tuzer, PhD

Aidan Bell, BS

Ferit Tuzer, PhD

Ferit Tuzer, PhD

John Kelly, MD

Ferit Tuzer, PhD

Joost de Bruijn, PhD

Joost de Bruijn, PhD

Joost de Bruijn, PhD

Joost de Bruijn, PhD

Michael Lark, PhD

Joost de Bruijn, PhD

Hannah Zlotnick, PhD

Hannah Zlotnick, PhD

Joost de Bruijn, PhD

Hannah Zlotnick, PhD

Contact Us

Mechano Therapeutics LLC

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