Harnessing the power of the body's own natural forces to deliver therapeutics
Mechano Therapeutics is a biotech company specializing in microcapsule development using proprietary microfluidics for drug encapsulation. Our mission is to revolutionize musculoskeletal health using our innovative platform technology to enhance delivery of therapeutics for improving patient outcomes.
Our microcapsule platform technology offers a totally new approach of delivering therapeutics by encapsulating existing and novel drugs into the articulating joint whereby it activates drug release with force or motion
Spun out of the University of Pennsylvania, we leveraged our understanding of mechanobiology and orthopedics to develop the first drug delivery system that uses natural mechanical forces of the joint to control delivery of therapeutics
The microcapsules are formed using a proprietary microfluidic technology and double emulsion process in which we can encapsulate and release nearly any soluble drug or therapeutic of choice. Ideal payloads include small molecules, proteins, and biologics. We can synthesize size-controlled microcapsules at a range of 50+ microns. Fabrication uses PLGA, an FDA-approved biodegradable polymer for over 30 years.
Directive therapy and fewer potential systemic side effects
Release drugs 'on demand' based on mechanical forces of the joint
Maintains drug concentrations within the therapeutic range and fewer joint injections
Preserves drug activity and improves drug efficacy in joint tissues
1. Mohanraj B, Duan G, Peredo A, et al. Mechanically-Activated Microcapsules for 'On-Demand' Drug Delivery in Dynamically Loaded Musculoskeletal Tissues. Advanced Functional Materials. 2019;29(15). doi: 10.1002/adfm.201807909. (Link)
2. Peredo AP, Jo YK, Duan G, Dodge GR, Lee D, Mauck RL. Mechano-activated biomolecule release in regenerating load-bearing tissue microenvironments. Biomaterials. 2021;265:120255. doi: 10.1016/j.biomaterials.2020.120255. (Link)
3. Jo YK , Heo SJ , Peredo AP , Mauck RL , Dodge GR , Lee D . Stretch-responsive adhesive microcapsules for strain-regulated antibiotic release from fabric wound dressings. Biomaterial Science. 2021 Aug 7;9(15):5136-5143. doi: 10.1039/d1bm00628b. (Link)
4. Zlotnick HM, Locke RC, Hemdev S, Stoeckl BD, Gupta S, Peredo AP, Steinberg DR, Carey JL, Lee D, Dodge GR, Mauck RL. Gravity-based patterning of osteogenic factors to preserve bone structure after osteochondral injury in a large animal model. Biofabrication. 2022 Jul 5;14(4):10.1088/1758-5090/ac79cd. doi: 10.1088/1758-5090/ac79cd. (Link)
PCT/US2016/035220 (USA) Mechano-sensitive microcapsules for drug delivery (filed: 12/1/2017)
PCT/US2016/035220 (Europe) Mechano-sensitive microcapsules for drug delivery (filed: 6/1/2016)
63/167,260 (USA) Mussel-inspired adhesive microcapsules for a stretch-responsive therapeutic delivery (filed: 3/29/21)
Expanding the applications of our proprietary microcapsule technology
Providing access and expertise on fundraising, IP management, and commercialization
Small Business Technology Transfer (STTR) Funding
CEO & Co-founder
CEO, Kuros Biosciences
President, Lark Pharma Consulting
Please send us a message to get in touch.
3401 Grays Ferry Ave Bldg 450, Philadelphia, PA 19146