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Revolutionizing Musculoskeletal Health through microcapsule drug delivery

Harnessing the power of the body's own natural forces to deliver therapeutics

About Us

Innovative Drug Delivery Technology

Mechano-Therapeutics is a biotech company focusing on delivery of therapeutics for a wide range of musculoskeletal tissue applications

Microcapsule Platform

Our microcapsule platform technology offers a totally new approach of delivering therapeutics by encapsulating existing and novel drugs into the articulating joint whereby it activates drug release with force or motion

University of Penn Start-Up

Spun out of the University of Pennsylvania, we leveraged our understanding of mechanobiology and orthopedics to develop the first drug delivery system that uses natural mechanical forces of the joint to control delivery of therapeutics

Our Technology

Mechano-Activated Microcapsules

The microcapsules are formed using a proprietary microfluidic technology and double emulsion process in which the inner aqueous solution contains nearly any drug or therapeutic of choice

Advantages of mamc delivery

Targeted & controlled local release

Directive therapy and fewer potential systemic side effects

Stimuli responsive drug activation

Targeted & controlled local release

Release drugs 'on demand' based on mechanical forces of the joint

Dose sparing

Sustained bioavailability & enhanced biocompatibility

Maintains drug concentrations within the therapeutic range and fewer joint injections

Sustained bioavailability & enhanced biocompatibility

Preserves drug activity and improves drug efficacy in joint tissues

Publications & Patents

1. Mohanraj B, Duan G, Peredo A, et al. Mechanically-Activated Microcapsules for 'On-Demand' Drug Delivery in Dynamically Loaded Musculoskeletal Tissues. Advanced Functional Materials. 2019;29(15). doi: 10.1002/adfm.201807909. (Link)

2. Peredo AP, Jo YK, Duan G, Dodge GR, Lee D, Mauck RL. Mechano-activated biomolecule release in regenerating load-bearing tissue microenvironments. Biomaterials. 2021;265:120255. doi: 10.1016/j.biomaterials.2020.120255. (Link)

3. Jo YK , Heo SJ , Peredo AP , Mauck RL , Dodge GR , Lee D . Stretch-responsive adhesive microcapsules for strain-regulated antibiotic release from fabric wound dressings. Biomaterial Science. 2021 Aug 7;9(15):5136-5143. doi: 10.1039/d1bm00628b. (Link)

Patents: Technology

PCT/US2016/035220 (USA) Mechano-sensitive microcapsules for drug delivery (filed: 12/1/2017)

PCT/US2016/035220 (Europe) Mechano-sensitive microcapsules for drug delivery (filed: 6/1/2016)

63/167,260 (USA) Mussel-inspired adhesive microcapsules for a stretch-responsive therapeutic delivery (filed: 3/29/21)

Drug Encapsulated MAMCs

Our Partners

Research & Development

Expanding the applications of our proprietary microcapsule technology

Business Development

Research & Development

Providing access and expertise on fundraising, IP management, and commercialization

Early-Stage Financing

Research & Development

Early-Stage Financing

Small Business Innovation Research (SBIR) grants

Our team

George Dodge, PhD

NicK DePhillipo, PhD, MBA

CEO & Co-founder

NicK DePhillipo, PhD, MBA

COO

Bhavana Mohanraj, PhD

NicK DePhillipo, PhD, MBA

Bhavana Mohanraj, PhD

Co-founder

Robert Mauck, PhD

Bhavana Mohanraj, PhD

Co-founder

Daeyeon Lee, PhD

Robert Mauck, PhD

Daeyeon Lee, PhD

Co-founder

John Kelly, MD

Robert Mauck, PhD

Daeyeon Lee, PhD

Advisor

Orthopedic Surgeon

Contact Us

Please send us a message to get in touch.

Mechano-Therapeutics LLC

3401 Grays Ferry Ave, Philadelphia, PA 19146

Revolutionizing Musculoskeletal Health through microcapsule drug delivery

About Us

Innovative Drug Delivery Technology

Microcapsule Platform

University of Penn Start-Up

Our Technology

Mechano-Activated Microcapsules

Advantages of mamc delivery

Targeted & controlled local release

Targeted & controlled local release

Targeted & controlled local release

Stimuli responsive drug activation

Targeted & controlled local release

Targeted & controlled local release

Dose sparing

Sustained bioavailability & enhanced biocompatibility

Sustained bioavailability & enhanced biocompatibility

Sustained bioavailability & enhanced biocompatibility

Sustained bioavailability & enhanced biocompatibility

Sustained bioavailability & enhanced biocompatibility

Publications & Patents

Patents: Technology

Drug Encapsulated MAMCs

Our Partners

Research & Development

Research & Development

Research & Development

Business Development

Research & Development

Research & Development

Early-Stage Financing

Research & Development

Early-Stage Financing

Our team

George Dodge, PhD

NicK DePhillipo, PhD, MBA

NicK DePhillipo, PhD, MBA

NicK DePhillipo, PhD, MBA

NicK DePhillipo, PhD, MBA

NicK DePhillipo, PhD, MBA

Bhavana Mohanraj, PhD

NicK DePhillipo, PhD, MBA

Bhavana Mohanraj, PhD

Robert Mauck, PhD

Robert Mauck, PhD

Bhavana Mohanraj, PhD

Daeyeon Lee, PhD

Robert Mauck, PhD

Daeyeon Lee, PhD

John Kelly, MD

Robert Mauck, PhD

Daeyeon Lee, PhD

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Contact Us

Mechano-Therapeutics LLC

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