Revolutionizing Musculoskeletal Health through microcapsule drug delivery
Harnessing the power of the body's own natural forces to deliver therapeutics
Harnessing the power of the body's own natural forces to deliver therapeutics
Mechano-Therapeutics is a biotech company focusing on delivery of therapeutics for a wide range of musculoskeletal tissue applications
Our microcapsule platform technology offers a totally new approach of delivering therapeutics by encapsulating existing and novel drugs into the articulating joint whereby it activates drug release with force or motion
Spun out of the University of Pennsylvania, we leveraged our understanding of mechanobiology and orthopedics to develop the first drug delivery system that uses natural mechanical forces of the joint to control delivery of therapeutics
The microcapsules are formed using a proprietary microfluidic technology and double emulsion process in which the inner aqueous solution contains nearly any drug or therapeutic of choice
Directive therapy and fewer potential systemic side effects
Release drugs 'on demand' based on mechanical forces of the joint
Maintains drug concentrations within the therapeutic range and fewer joint injections
Preserves drug activity and improves drug efficacy in joint tissues
1. Mohanraj B, Duan G, Peredo A, et al. Mechanically-Activated Microcapsules for 'On-Demand' Drug Delivery in Dynamically Loaded Musculoskeletal Tissues. Advanced Functional Materials. 2019;29(15). doi: 10.1002/adfm.201807909. (Link)
2. Peredo AP, Jo YK, Duan G, Dodge GR, Lee D, Mauck RL. Mechano-activated biomolecule release in regenerating load-bearing tissue microenvironments. Biomaterials. 2021;265:120255. doi: 10.1016/j.biomaterials.2020.120255. (Link)
3. Jo YK , Heo SJ , Peredo AP , Mauck RL , Dodge GR , Lee D . Stretch-responsive adhesive microcapsules for strain-regulated antibiotic release from fabric wound dressings. Biomaterial Science. 2021 Aug 7;9(15):5136-5143. doi: 10.1039/d1bm00628b. (Link)
PCT/US2016/035220 (USA) Mechano-sensitive microcapsules for drug delivery (filed: 12/1/2017)
PCT/US2016/035220 (Europe) Mechano-sensitive microcapsules for drug delivery (filed: 6/1/2016)
63/167,260 (USA) Mussel-inspired adhesive microcapsules for a stretch-responsive therapeutic delivery (filed: 3/29/21)
Expanding the applications of our proprietary microcapsule technology
Providing access and expertise on fundraising, IP management, and commercialization
Small Business Innovation Research (SBIR) grants
CEO & Co-founder
COO
Co-founder
Co-founder
Co-founder
Advisor
Orthopedic Surgeon
Please send us a message to get in touch.
3401 Grays Ferry Ave, Philadelphia, PA 19146
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